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Stress can kill brain cells
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Stress contributes to depression by killing new nerve
cells in the hippocampus, the area that processes
learning, memory and emotion.
Research suggests that in young rats, the stress of
encountering older, aggressive rats didn't stop the
creation of new brain nerve cells, the first step in a
process called neurogenesis. However, this form of
stress did prevent many new nerve cells from surviving,
which left the young rats with fewer neurons for
processing feelings and emotions.
This negative impact on neurogenesis could be a cause of
depression, said senior study author Daniel Peterson, of
the Rosalind Franklin University of Medicine and
Science, near Chicago.
Stress-linked brain cell destruction doesn't happen
immediately, however. "This is strong evidence that the
effects of social stress on neurogenesis occur after a
delay of 24 hours or more, providing a possible time
window for treatment after acute episodes of stress,"
Henriette van Praag, of the Salk Institute for
Biological Sciences, said in a prepared statement.
Peterson said the next step in this research is to try
to investigate how stress reduced the survival of the
new nerve cells.
"We want to determine if antidepressant medications
might be able to keep these vulnerable new neurons
alive," Peterson said.
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